Introduction to Module 4

Module-level Objectives

As a result of the instruction in this module, students will be able to:

Ch 6 Describe the criteria that distinguishes a macrocytic anemia as megaloblastic

Compare and contrast the morphologic characteristics of megaloblastic and normoblasts in the BM

Differentiate red blood cell and white blood cell changes in the peripheral smear that are seen in the megaloblastic anemias.

Describe ineffective hematopoiesis as it relates to the megaloblastic process

Characterize the clinical symptoms of a patient with megaloblastic anemia

List the causes of B12 and folic acid deficiency

Define pernicious anemia and its clinical and laboratory findings.

Describe relevant laboratory tests used in the diagnosis of megaloblastic anemia

Summarize treatments for the megaloblastic anemias

Differentiate the anemias that are macrocytic but are not megaloblastic.

Review the function of the spleen as they relate to RBC membrane integrity.

Identify the RBC membrane defect in hereditary spherocytosis, stomatocytosis, elliptocytosis, pyropoikilocytosis.

Describe the clinical findings and laboratory data in patients with hereditary spherocytosis.

Describe the osmotic fragility test and its clinical usefulness.

Compare and contrast the clinical and peripheral smear findings from hereditary stomatocytosis, elliptocytosis and pyropoikilocytosis.

Define the pathophysiology of the RBC biochemical disorders

Describe the mutations and ethnic distinctions in glucose-6-phosphate dehydrogenase deficiency.

Ch 7

Differentiate the anemias that are macrocytic but are not megaloblastic.

Review the function of the spleen as they relate to RBC membrane integrity.

Identify the RBC membrane defect in hereditary spherocytosis, stomatocytosis, elliptocytosis, pyropoikilocytosis.

Describe the clinical findings and laboratory data in patients with hereditary spherocytosis.

Describe the osmotic fragility test and its clinical usefulness.

Compare and contrast the clinical and peripheral smear findings from hereditary stomatocytosis, elliptocytosis and pyropoikilocytosis.

Define the pathophysiology of the RBC biochemical disorders

Describe the mutations and ethnic distinctions in glucose-6-phosphate dehydrogenase deficiency

(CO = Course Objective. This demonstrates the alignment from the module objective to the course objective[s].)

To Do

All activities in this module are required unless otherwise noted. If you have questions or ideas, prior to contacting the instructor, please post to the FAQ Discussion. Complete the following: